Protein Details: Amiloride-sensitive sodium channel subunit beta

Protein ID

ICDB_Pro_0578

Protein Name

Amiloride-sensitive sodium channel subunit beta

Gene Name

scnn1b-a

Organism

Xenopus laevis (African clawed frog)

Length

647 amino acids

AlphaFoldDB

AF-P51169-F1-model_v4.pdb

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.

Sequence

MIHGKMKRLKRYFTRALHRIQKGPGYTYKELLVWFCDNTNTHGPKRIIKEGPKKRVMWFILTLVFAGLVFWQWGVLILTYLSYGVSVSLSIGFKTMEFPAVTLCNANPFKYSRVKPLLKELDELVATALDRIQFSSQNQGNTFTHNNQTRQNVTLDPALWNHIPLVVIDETDPRNPIIHNIFDNNAVYSKNSSIRNSSEDQTSYSQRYKVAMKLCTNNNTQCVYRNFTSGVQALREWYLLQLSSIFSNVPLSGRIDMGFKAEDLILTCLFGGQPCSYRNFTHIYDADYGNCYIFNWGQEGENTMSSANPGADFGLKLVLDIEQGEYLPFLQTTAAARLILHQQRSFPFVKDLGIYAMPGTETSISVLVDQLEHMEAPYSSCTVNGSDIPVQNLYAEFNSSYSIQSCLRSCYQEEMVKTCKCAHYQYPLPNGSEYCTNMKHPDWVPCYYSLRDSVAIRENCISLCQQPCNDTHYKMVISMADWPSAGAEDWIFHVLSYEKDSSHNITVNRNGIVRLNIYFQEFNYRSISESEATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEIIIDCMWITILKFLAWSRNRRQRRKRPQYSDPPPTVSELVEAHTNSGFQHDDGDHVPVDIPGTPPPNYDSLRVNTAEPVSSDEEN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1152/ajpcell.1995.269.1.c188